Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
| Title: | Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma |
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| Authors: | Dawn Swan, Mark Gurney, Janusz Krawczyk, Aideen E. Ryan, Michael O’Dwyer |
| Source: | HemaSphere, Vol 4, Iss 2, p e350 (2020) |
| Publisher Information: | Wiley, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | Abstract. The alkylating agent cyclophosphamide has been used in the treatment of multiple myeloma for over 60 years. At low doses, cyclophosphamide also has significant immunomodulatory activity, which can be used to modify the immunosuppressive tumor microenvironment in order to augment responses to existing therapies. Immune-mediated therapies are becoming more widespread in modern approaches to myeloma treatment. In this review, we discuss the effects cyclophosphamide has on the immune system, and how it can be used synergistically with other treatment modalities including the immunomodulatory agents, monoclonal antibodies and cellular therapies. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2572-9241 00000000 |
| Relation: | http://journals.lww.com/10.1097/HS9.0000000000000350; https://doaj.org/toc/2572-9241 |
| DOI: | 10.1097/HS9.0000000000000350 |
| Access URL: | https://doaj.org/article/57d9331d24ec4e129c0aba735d72de5f |
| Accession Number: | edsdoj.57d9331d24ec4e129c0aba735d72de5f |
| Database: | Directory of Open Access Journals |
| ISSN: | 25729241 00000000 |
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| DOI: | 10.1097/HS9.0000000000000350 |
| Published in: | HemaSphere |
| Language: | English |