Bibliographic Details
| Title: |
Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway |
| Authors: |
Bo Peng, Li Rao, Jiaolong Yang, Xiaowei Ku, Bin Kong, Wei Shuai, He Huang |
| Source: |
Acta Cirúrgica Brasileira, Vol 38 (2023) |
| Publisher Information: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Surgery |
| Subject Terms: |
Doxorubicin, Cardiotoxicity, Oxidative Stress, Apoptosis, Sirtuin 1, Surgery, RD1-811 |
| More Details: |
ABSTRACT Purpose: Oxidative stress and apoptosis contribute to the pathological basis of doxorubicin (DOX)-induced cardiotoxicity. Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens. Herein, we intended to explore the potential role and molecular basis of CBN in DOX-induced cardiotoxicity. Methods: C57BL/6 mice were subjected to DOX (15 mg/kg/day, i.p.) to generate DOX-induced cardiotoxicity. CBN (10 mg/kg/day, i.p.) was administered for four week following DOX injection. Results: DOX administered markedly dampened cardiac function, increased cardiac injury, excessive reactive oxygen species (ROS) production, and cardiomyocyte loss. These alterations induced by DOX significantly alleviated by CBN treatment. Mechanistically, our results demonstrated that the CBN exerts cardioprotection role against DOX by up-regulating silent information regulator 1 (Sirt1) and decreasing acetylation of forkhead box O1 (FOXO1). Moreover, Sirt1 inhibition with Ex-527 significantly blunt the beneficial effect of CBN on DOX-induced cardiotoxicity, including cardiac dysfunction, ROS, and apoptosis. Conclusion: Collectively, CBN attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity through maintaining Sirt1/FOXO1 signaling pathway. Our results demonstrated that CBN might be used to treat DOX-related cardiotoxicity. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1678-2674 |
| Relation: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100217&tlng=en; https://doaj.org/toc/1678-2674 |
| DOI: |
10.1590/acb382223 |
| Access URL: |
https://doaj.org/article/eca57bf803b34274ad94e6395ea46662 |
| Accession Number: |
edsdoj.57bf803b34274ad94e6395ea46662 |
| Database: |
Directory of Open Access Journals |
