Bibliographic Details
| Title: |
Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts |
| Authors: |
Alessio Alesci, Gioele Capillo, Angelo Fumia, Emmanuele Messina, Marco Albano, Marialuisa Aragona, Patrizia Lo Cascio, Nunziacarla Spanò, Simona Pergolizzi, Eugenia Rita Lauriano |
| Source: |
Biology, Vol 11, Iss 7, p 1045 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
comparative immunology, dendritic cells, evolution, immunity, confocal microscopy, Biology (General), QH301-705.5 |
| More Details: |
Dendritic cells (DCs) are antigen-presenting cells (APCs) that regulate the beginning of adaptive immune responses. The mechanisms of tolerance to antigens moving through the digestive tract are known to be regulated by intestinal DCs. Agnatha and Gnathostoma are descendants of a common ancestor. The Ostracoderms gave rise to Cyclostomes, whereas the Placoderms gave rise to Chondrichthyes. Sarcopterygii and Actinopterygii are two evolutionary lines of bony fishes. Brachiopterygii and Neopterygii descend from the Actinopterygii. From Neopterygii, Holostei and Teleostei evolved. Using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II, this study aimed to characterize intestinal DCs, from myxines to teleosts. The findings reveal that DCs are positive for the antibodies tested, highlighting the presence of DCs and DC-like cells phylogenetically from myxines, for the first time, to teleosts. These findings may aid in improving the level of knowledge about the immune system’s evolution and these sentinel cells, which are crucial to the body’s defense. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2079-7737 |
| Relation: |
https://www.mdpi.com/2079-7737/11/7/1045; https://doaj.org/toc/2079-7737 |
| DOI: |
10.3390/biology11071045 |
| Access URL: |
https://doaj.org/article/5793398b7bc64e6c96ab6ca6368714f5 |
| Accession Number: |
edsdoj.5793398b7bc64e6c96ab6ca6368714f5 |
| Database: |
Directory of Open Access Journals |
