Bibliographic Details
| Title: |
GLUT-1 may predict metastases and death in patients with locally advanced rectal cancer |
| Authors: |
Tae Hyun Kim, Yoonjin Kwak, Changhoon Song, Hye Seung Lee, Duck-Woo Kim, Heung-Kwon Oh, Jin Won Kim, Keun-Wook Lee, Sung-Bum Kang, Jae-Sung Kim |
| Source: |
Frontiers in Oncology, Vol 13 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Glucose transporter-1 (GLUT-1), neoadjuvant chemoradiation (CRT), rectal cancer (RC), survival, metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
IntroductionGlucose transporter-1 (GLUT-1) has been studied as a possible predictor for survival outcomes in locally advanced rectal cancer (LARC).MethodsWe aimed to investigate the prognostic role of GLUT-1 in LARC using the data of 208 patients with clinical T3–4 stage and/or node-positive rectal adenocarcinoma, all of whom underwent neoadjuvant chemoradiotherapy (CRT) and subsequent total mesorectal excision (TME). Both pre-CRT and post-CRT specimens were immunohistologically stained for GLUT-1. Patients were classified into GLUT-1-positive and GLUT-1-negative groups and distant metastasis-free survival (DMFS) and overall survival (OS) was analyzed and compared.ResultsAt a median follow-up of 74 months, post-CRT GLUT-1 status showed a significant correlation with worse DMFS (p=0.027, HR 2.26) and OS (p=0.030, HR 2.30). When patients were classified into 4 groups according to yp stage II/III status and post-CRT GLUT-1 positivity [yp stage II & GLUT-1 (-), yp stage II & GLUT-1 (+), yp stage III & GLUT-1 (-), yp stage III & GLUT-1 (+)], the 5-year DMFS rates were 92.3%, 63.9%, 65.4%, and 46.5%, respectively (p=0.013). GLUT-1 (-) groups showed markedly better outcomes for both yp stage II and III patients compared to GLUT-1 (+) groups. A similar tendency was observed for OS.DiscussionIn conclusion, post-CRT GLUT-1 may serve as a prognostic marker in LARC. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2023.1094480/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2023.1094480 |
| Access URL: |
https://doaj.org/article/571831b147424daf90690a61218cc4a1 |
| Accession Number: |
edsdoj.571831b147424daf90690a61218cc4a1 |
| Database: |
Directory of Open Access Journals |
