Academic Journal
Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence
| Title: | Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence |
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| Authors: | Milly N. Kanobe, Bobbette A. Jones, Paul Nelson, Buddy G. Brown, Peter Chen, Patrudu Makena, Eckhardt Schmidt, John Darnell, John W. Caraway, G. L. Prasad, Brian Nordskog, Elaine K. Round |
| Source: | Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Biomarkers of exposure (BoE) can help evaluate exposure to combustion-related, tobacco-specific toxicants after smokers switch from cigarettes to potentially less-harmful products like electronic nicotine delivery systems (ENDS). This paper reports data for one (Vuse Solo Original) of three products evaluated in a randomized, controlled, confinement study of BoE in smokers switched to ENDS. Subjects smoked their usual brand cigarette ad libitum for two days, then were randomized to one of three ENDS for a 7-day ad libitum use period, or to smoking abstinence. Thirteen BoE were assessed at baseline and Day 5, and percent change in mean values for each BoE was calculated. Biomarkers of potential harm (BoPH) linked to oxidative stress, platelet activation, and inflammation were also assessed. Levels decreased among subjects randomized to Vuse Solo versus Abstinence, respectively, for the following BoE: 42–96% versus 52–97% (non-nicotine constituents); 51% versus 55% (blood carboxyhemoglobin); and 29% versus 96% (nicotine exposure). Significant decreases were observed in three BoPH: leukotriene E4, 11-dehydro-thromboxane B2, and 2,3-dinor thromboxane B2 on Day 7 in the Vuse Solo and Abstinence groups. These findings show that ENDS use results in substantially reduced exposure to toxicants compared to smoking, which may lead to reduced biological effects. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-25054-z |
| Access URL: | https://doaj.org/article/5711772059b24610b8ba38cc171fdc22 |
| Accession Number: | edsdoj.5711772059b24610b8ba38cc171fdc22 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-022-25054-z |
| Published in: | Scientific Reports |
| Language: | English |