Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study

Bibliographic Details
Title: Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
Authors: Vasiliki Mamakou, Sophie Hackinger, Eleni Zengini, Evgenia Tsompanaki, Eirini Marouli, Ioannis Serafetinidis, Bram Prins, Athina Karabela, Eirini Glezou, Lorraine Southam, Nigel W. Rayner, Karoline Kuchenbaecker, Klea Lamnissou, Vassilis Kontaxakis, George Dedoussis, Fragiskos Gonidakis, Anastasia Thanopoulou, Nikolaos Tentolouris, Eleftheria Zeggini
Source: BMC Psychiatry, Vol 18, Iss 1, Pp 1-9 (2018)
Publisher Information: BMC, 2018.
Publication Year: 2018
Collection: LCC:Psychiatry
Subject Terms: Type 2 diabetes, Schizophrenia, First generation antipsychotics, Second generation antipsychotics, Antidepressants, Mood stabilizers, Psychiatry, RC435-571
More Details: Abstract Background Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet been evaluated. The overarching goal of the Genetic Overlap between Metabolic and Psychiatric disease (GOMAP) study is to assess the effect of pharmacological, anthropometric, lifestyle and clinical measurements, helping elucidate the mechanisms underlying the aetiology of T2D. Methods The GOMAP case-control study (Genetic Overlap between Metabolic and Psychiatric disease) includes hospitalized patients with SCZ, some of whom have T2D. We enrolled 1653 patients with SCZ; 611 with T2D and 1042 patients without T2D. This is the first study of SCZ and T2D comorbidity at this scale in the Greek population. We retrieved detailed information on first- and second-generation antipsychotics (FGA, SGA), antidepressants and mood stabilizers, applied as monotherapy, 2-drug combination, or as 3- or more drug combination. We assessed the effects of psychotropic medication, body mass index, duration of schizophrenia, number of hospitalizations and physical activity on risk of T2D. Using logistic regression, we calculated crude and adjusted odds ratios (OR) to identify associations between demographic factors and the psychiatric medications. Results Patients with SCZ on a combination of at least three different classes of psychiatric drugs had a higher risk of T2D [OR 1.81 (95% CI 1.22–2.69); p = 0.003] compared to FGA alone therapy, after adjustment for age, BMI, sex, duration of SCZ and number of hospitalizations. We did not find evidence for an association of SGA use or the combination of drugs belonging to two different classes of psychiatric medications with increased risk of T2D [1.27 (0.84–1.93), p = 0.259 and 0.98 (0.71–1.35), p = 0.885, respectively] compared to FGA use. Conclusions We find an increased risk of T2D in patients with SCZ who take a combination of at least three different psychotropic medication classes compared to patients whose medication consists only of one or two classes of drugs.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1471-244X
Relation: http://link.springer.com/article/10.1186/s12888-018-1826-4; https://doaj.org/toc/1471-244X
DOI: 10.1186/s12888-018-1826-4
Access URL: https://doaj.org/article/c570450c1dd64cc19c48500a135ea39c
Accession Number: edsdoj.570450c1dd64cc19c48500a135ea39c
Database: Directory of Open Access Journals
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More Details
ISSN:1471244X
DOI:10.1186/s12888-018-1826-4
Published in:BMC Psychiatry
Language:English