Bibliographic Details
| Title: |
Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ |
| Authors: |
Cristian Gabriel Beccaria, María Carolina Amezcua Vesely, Facundo Fiocca Vernengo, Ricardo Carlos Gehrau, María Cecilia Ramello, Jimena Tosello Boari, Melisa Gorosito Serrán, Juan Mucci, Eliane Piaggio, Oscar Campetella, Eva Virginia Acosta Rodríguez, Carolina Lucía Montes, Adriana Gruppi |
| Source: |
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| Publisher Information: |
Nature Portfolio, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-018-04063-5 |
| Access URL: |
https://doaj.org/article/e56f9c7562ff48e1b8ef2534da1247d2 |
| Accession Number: |
edsdoj.56f9c7562ff48e1b8ef2534da1247d2 |
| Database: |
Directory of Open Access Journals |
