Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable, unfavorable intermediate- and high-risk prostate cancer across United States SEER registries
| Title: | Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable, unfavorable intermediate- and high-risk prostate cancer across United States SEER registries |
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| Authors: | Rocco Simone Flammia, Benedikt Hoeh, Francesco Chierigo, Lukas Hohenhorst, Gabriele Sorce, Zhen Tian, Costantino Leonardo, Markus Graefen, Carlo Terrone, Fred Saad, Shahrokh F. Shariat, Alberto Briganti, Francesco Montorsi, Felix K. H. Chun, Michele Gallucci, Pierre I. Karakiewicz |
| Source: | Current Urology, Vol 16, Iss 4, Pp 191-196 (2022) |
| Publisher Information: | Wolters Kluwer Health, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Abstract. Background. The National Comprehensive Cancer Network (NCCN) guidelines recommend pelvic lymph node dissection (PLND) in NCCN high- and intermediate-risk prostate cancer patients. We tested for PLND nonadherence (no-PLND) rates within the Surveillance Epidemiology and End Results (2010–2015). Materials and methods. We identified all radical prostatectomy patients who fulfilled the NCCN PLND guideline criteria (n = 23,495). Nonadherence rates to PLND were tabulated and further stratified according to NCCN risk subgroups, race/ethnicity, geographic distribution, and year of diagnosis. Results. Overall, the no-PLND rate was 26%; it was 41%, 25%, and 11% in the NCCN intermediate favorable, intermediate unfavorable, and high-risk prostate cancer patients, respectively (p < 0.001). Over time, the no-PLND rates declined in the overall cohort and within each NCCN risk subgroup. Georgia exhibited the highest no-PLND rate (49%), whereas New Jersey exhibited the lowest (15%). Finally, no-PLND race/ethnicity differences were recorded only in the NCCN intermediate unfavorable subgroup, where Asians exhibited the lowest no-PLND rate (20%) versus African Americans (27%) versus Whites (26%) versus Hispanic-Latinos (25%). Conclusions. The lowest no-PLND rates were recorded in the NCCN high-risk patients followed by NCCN intermediate unfavorable and favorable risk in that order. Our findings suggest that unexpectedly elevated differences in no-PLND rates warrant further examination. In all the NCCN risk subgroups, the no-PLND rates decreased over time. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1661-7649 00000000 |
| Relation: | http://journals.lww.com/10.1097/CU9.0000000000000132; https://doaj.org/toc/1661-7649 |
| DOI: | 10.1097/CU9.0000000000000132 |
| Access URL: | https://doaj.org/article/a56c9b8e0d404091b331323e993e7f0f |
| Accession Number: | edsdoj.56c9b8e0d404091b331323e993e7f0f |
| Database: | Directory of Open Access Journals |
| ISSN: | 16617649 00000000 |
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| DOI: | 10.1097/CU9.0000000000000132 |
| Published in: | Current Urology |
| Language: | English |