Bibliographic Details
| Title: |
Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas |
| Authors: |
Simon L. Barry, Emer Lynch, Philip Bredin, Sebastian McWilliams, Julie McCarthy, Orla O’Mahony, Linda Feeley, Killian Nugent, Patrick Sheahan, Deirdre O’Hanlon, David O’Reilly, Seamus O’Reilly |
| Source: |
Onco, Vol 4, Iss 4, Pp 427-438 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
anaplastic thyroid carcinoma, targeted therapy, perforation, complications, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-7523 |
| Relation: |
https://www.mdpi.com/2673-7523/4/4/30; https://doaj.org/toc/2673-7523 |
| DOI: |
10.3390/onco4040030 |
| Access URL: |
https://doaj.org/article/566ca5c2df34438e99af4d01e02e1103 |
| Accession Number: |
edsdoj.566ca5c2df34438e99af4d01e02e1103 |
| Database: |
Directory of Open Access Journals |
