Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy
| Title: | Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy |
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| Authors: | Muhammad Sohail, Bin Yu, Zheng Sun, Jiali Liu, Yanli Li, Feng Zhao, Daquan Chen, Xin Yang, Hui Xu |
| Source: | Drug Delivery, Vol 29, Iss 1, Pp 1523-1535 (2022) |
| Publisher Information: | Taylor & Francis Group, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | Complex polymeric nanomicelles, doxorubicin, dimethoxycurcumin, combinational cancer chemotherapy, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Combinational therapy is a new trend in medical sciences to achieve a maximum therapeutic response of the drugs with a comparatively low incidence of severe adverse effects. To overcome the challenges of conventional formulations for cancer chemotherapy, a polymer-based complex nanomicellar system, namely CPM-DD, was developed co-delivering the anti-cancer agent doxorubicin (DOX) and potent antioxidant dimethoxycurcumin (DiMC). The optimal mass ratio of DOX/DiMC in CPM-DD was determined as 1:6 due to the synergistic antiproliferative effect from in vitro cytotoxicity assay, while the biocompatible diblock copolymer of mPEG2000-PLA5000 was selected for drug entrapment at an optimal feeding ratio of 9:1 to both drugs together. The uniform particles of CPM-DD with suitable particle size (∼30 nm) and stable drug loading content (>9%) could be reliably obtained by self-assembly with the encapsulation yield up to 95%. Molecular dynamics simulation revealed the interaction mechanism responsible for forming these complex nanomicelles. The acid-base interaction between two drugs would significantly improve their binding with the copolymer, thus leading to good colloidal stability and controlled drug release characteristics of CPM-DD. Systematic evaluation based on the MCF-7 breast tumor-bearing nude mice model further demonstrated the characteristics of tissue biodistribution of both drugs delivered by CPM-DD, which were closely related to the drug loading pattern and greatly responsible for the improved anti-cancer potency and attenuated toxicity of this complex formulation. Therefore, all the findings indicated that CPM-DD would be a good alternative to the conventional formulations of DOX and worthy of clinical application for cancer chemotherapy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 10717544 1521-0464 1071-7544 |
| Relation: | https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464 |
| DOI: | 10.1080/10717544.2022.2073403 |
| Access URL: | https://doaj.org/article/5652d8133ae84be595ec3c676e3091aa |
| Accession Number: | edsdoj.5652d8133ae84be595ec3c676e3091aa |
| Database: | Directory of Open Access Journals |
| ISSN: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2022.2073403 |
| Published in: | Drug Delivery |
| Language: | English |