Bibliographic Details
| Title: |
A case of mood disorder with severe side effects of antidepressants in association with resistance to thyroid hormone beta with a THRB mutation |
| Authors: |
Hazuki Komahashi‐Sasaki, Norio Yasui‐Furukori, Ryo Maehara, Chie Hasegawa, Kazutaka Shimoda |
| Source: |
Neuropsychopharmacology Reports, Vol 42, Iss 3, Pp 391-394 (2022) |
| Publisher Information: |
Wiley, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Therapeutics. Pharmacology
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
antidepressants, depression, Refetoff syndrome, RTHβ, side effects, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Abstract Background Although resistance to thyroid hormone beta (RTHβ) is associated with attention‐deficit/hyperactivity disorder, there are few reports of other concomitant mood disorders in individuals with RTHβ. Case presentation A 67‐year‐old woman who had been previously diagnosed with RTHβ (Refetoff syndrome) came to our department as a depressed patient. She was hospitalized twice for depression and treated with antidepressants both times. Paroxetine (37.5 mg/day) treatment during the first hospitalization did not cause any side effects, but treatment with mirtazapine (15 mg/day) and venlafaxine (150 mg/day) during the second hospitalization caused clonus and disturbance of consciousness, and these adverse effects resulted in a prolonged period of hospitalization. Finally, the patient’s symptoms were controlled with quetiapine (75 mg/day). Conclusion Poor tolerability to antidepressants was observed, which may be related to thyroid hormone intolerance. Low doses of quetiapine may contribute to improvements in depression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2574-173X |
| Relation: |
https://doaj.org/toc/2574-173X |
| DOI: |
10.1002/npr2.12280 |
| Access URL: |
https://doaj.org/article/56495d028e9b4e618937f6e3494edf3c |
| Accession Number: |
edsdoj.56495d028e9b4e618937f6e3494edf3c |
| Database: |
Directory of Open Access Journals |
