Bibliographic Details
| Title: |
Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain |
| Authors: |
Gendi Wang, Xiang Chen, Xiaoyuan Wang, Yinghui Duan, Hanqing Gao, Xiaopei Ji, Yunfei Zhu, Xuanyi Xiang, Hairong Ma, Yonggang Li, Qun Xue |
| Source: |
Frontiers in Neurology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
neuromyelitis optica spectrum disorder, neuropathic pain, amplitude of low-frequency fluctuations, anterior insula, amygdala, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
BackgroundNeuropathic pain is one of the most common symptoms in neuromyelitis optica spectrum disorder (NMOSD). Notwithstanding, its underlying mechanism remains obscure.MethodsThe amplitude of low-frequency fluctuations (ALFF) metric was employed to investigate spontaneous neural activity alterations via resting-state functional magnetic resonance imaging (rs-MRI) data from a 3.0 T MRI scanner, in a sample of 26 patients diagnosed with NMOSD with neuropathic pain (NMOSD-WNP), 20 patients with NMOSD but without neuropathic pain (NMOSD-WoNP), and 38 healthy control (HC) subjects matched for age and sex without the comorbidity of depressive or anxious symptoms.ResultsIt was observed that patients with NMOSD-WNP displayed a significant ALFF decrease in the left amygdala and right anterior insula, relative to both patients with NMOSD-WoNP and HC subjects. Furthermore, ALFF values in the left amygdala were negatively correlated with the scores of the Douleur Neuropathique en 4 Questions and McGill Pain Questionnaire (both sensory and affective descriptors) in patients with NMOSD-WNP. Additionally, there were negative correlations between the ALFF values in the right anterior insula and the duration of pain and the number of relapses in patients with NMOSD-WNP.ConclusionThe present study characterizes spontaneous neural activity changes in brain regions associated with sensory and affective processing of pain and its modulation, which underscore the central aspects in patients with NMOSD-WNP. These findings might contribute to a better understanding of the pathophysiologic basis of neuropathic pain in NMOSD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fneur.2024.1408759/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2024.1408759 |
| Access URL: |
https://doaj.org/article/562c38b118854ccfb022675539686c98 |
| Accession Number: |
edsdoj.562c38b118854ccfb022675539686c98 |
| Database: |
Directory of Open Access Journals |
