Bibliographic Details
| Title: |
Improved survival of patients with newly diagnosed oligometastatic prostate cancer through intensified multimodal treatment |
| Authors: |
Viktoria Schütz, Christopher-Leo Nessler, Anette Duensing, Stefanie Zschäbitz, Dirk Jäger, Jürgen Debus, Markus Hohenfellner, Stefan Duensing |
| Source: |
Frontiers in Oncology, Vol 14 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
oligometastatic prostate cancer, radical prostatectomy, multimodal treatment, intensified treatment, prostate cancer, hormone sensitive prostate cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Background and objectivesThe standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT), novel antihormonal therapies (NHT) and/or chemotherapy. Patients with newly diagnosed oligometastatic prostate cancer (omPCa) represent a distinct subgroup of mHSPC, for which the optimal treatment, particularly the role of radical prostatectomy (RP) and metastasis-directed therapy (MDT), is currently under debate.Materials and methodsIn this single center, retrospective analysis, 43 patients with newly diagnosed omPCa were included. All patients underwent RP as part of a multimodal, personalized treatment approach. Other treatments included ADT, NHT, MDT (surgery or radiotherapy), adjuvant radiotherapy (prostatic fossa and/or pelvic lymph nodes) or chemotherapy in various combinations. Clinical endpoints were progression free and cancer specific survival (PFS, CSS).ResultsNo patient with omPCa died from prostate cancer during an up to ten years follow-up period after intensified multimodal treatment i.e., RP, ADT, adjuvant radiation therapy and MDT (n=13). In contrast, patients requiring chemotherapy (n=10) showed a significantly worse PFS (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2024.1475914/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2024.1475914 |
| Access URL: |
https://doaj.org/article/55526ddb1a4544fcb376b9317bf51d81 |
| Accession Number: |
edsdoj.55526ddb1a4544fcb376b9317bf51d81 |
| Database: |
Directory of Open Access Journals |
