Academic Journal
Association between oncogenic human papillomavirus type 16 and Killian polyp
| Title: | Association between oncogenic human papillomavirus type 16 and Killian polyp |
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| Authors: | Lucia Oton-Gonzalez, John Charles Rotondo, Luca Cerritelli, Nicola Malagutti, Carmen Lanzillotti, Ilaria Bononi, Andrea Ciorba, Chiara Bianchini, Chiara Mazziotta, Monica De Mattei, Stefano Pelucchi, Mauro Tognon, Fernanda Martini |
| Source: | Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-9 (2021) |
| Publisher Information: | BMC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Infectious and parasitic diseases |
| Subject Terms: | Killian polyp, Human papillomavirus, Polyomavirus, Infection, Nasal polyps, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Infectious and parasitic diseases, RC109-216 |
| More Details: | Abstract Background Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. Methods DNA from antral (n = 14) and nasal (n = 14) KP fractions were analyzed for HPV and HPyV sequences, genotypes, viral DNA load and physical status along with expression of viral proteins and p16 cellular protein. Results The oncogenic HPV16 was detected in 3/14 (21.4%) antral KPs, whilst nasal KPs tested HPV-negative (0/14). The mean HPV16 DNA load was 4.65 ± 2.64 copy/104 cell. The whole HPV16 episomal genome was detected in one KP sample, whereas HPV16 DNA integration in two KPs. P16 mRNA level was lower in the KP sample carrying HPV16 episome than in KPs carrying integrated HPV16 and HPV- negative KPs (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1750-9378 |
| Relation: | https://doaj.org/toc/1750-9378 |
| DOI: | 10.1186/s13027-020-00342-3 |
| Access URL: | https://doaj.org/article/d550ee448cf644c49aefe8ea20ffdcc5 |
| Accession Number: | edsdoj.550ee448cf644c49aefe8ea20ffdcc5 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17509378 |
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| DOI: | 10.1186/s13027-020-00342-3 |
| Published in: | Infectious Agents and Cancer |
| Language: | English |