Loss of heterozygosity in acute leukemia: evidence of frequent submicroscopic deletions
| Title: | Loss of heterozygosity in acute leukemia: evidence of frequent submicroscopic deletions |
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| Authors: | Cecilia Agueli, Rosaria Basiricò, Francesco Fabbiano, Valentina Rizzo, Lucia Cascio, Giuseppe Cammarata, Anna Marfia, Maria La Rosa, Salvo Mirto, Alessandra Santoro |
| Source: | Haematologica, Vol 92, Iss 5 (2007) |
| Publisher Information: | Ferrata Storti Foundation, 2007. |
| Publication Year: | 2007 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | Although chromosomal abnormalities are detected by conventional cytogenetic analysis (CCA) in 40–60% of patients with acute myeloid leukemia (AML), cryptic chromosomal deletions may only be detected by molecular analysis. To determine their frequency, we studied 74 cases of AML by microsatellite allelotype assay using 35 microsatellites spanning eight chromosomal regions known to be frequently involved in AML. In 42 (57%) we found DNA imbalance at the screened loci. This was detected by CCA only in 4 cases. Our data show that cryptic deletions are a common event in AML. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0390-6078 1592-8721 |
| Relation: | https://haematologica.org/article/view/4441; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721 |
| DOI: | 10.3324/haematol.11028 |
| Access URL: | https://doaj.org/article/54e7430b13a9463e8083122880a7e756 |
| Accession Number: | edsdoj.54e7430b13a9463e8083122880a7e756 |
| Database: | Directory of Open Access Journals |
| ISSN: | 03906078 15928721 |
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| DOI: | 10.3324/haematol.11028 |
| Published in: | Haematologica |
| Language: | English |