Association of breast cancer grade with response to neoadjuvant chemotherapy assessed postoperatively
Title: | Association of breast cancer grade with response to neoadjuvant chemotherapy assessed postoperatively |
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Authors: | Michał Jarząb, Ewa Stobiecka, Agnieszka Badora-Rybicka, Ewa Chmielik, Małgorzata Kowalska, Wiesław Bal, Anna Polakiewicz-Gilowska, Barbara Bobek-Billewicz, Dariusz Lange, Rafał Tarnawski |
Source: | Polish Journal of Pathology, Vol 70, Iss 2, Pp 91-99 (2019) |
Publisher Information: | Termedia Publishing House, 2019. |
Publication Year: | 2019 |
Collection: | LCC:Medicine |
Subject Terms: | breast cancer, preoperative chemotherapy, grading, Medicine |
More Details: | Currently, breast cancer chemotherapy response can be predicted based on various parameters, with common reporting of tumour grade and Ki67 proliferation index. We analysed their association with pathological complete response (pCR) in a multivariate approach. The study was carried out in a group of 353 patients, treated by preoperative chemotherapy and prospectively observed. In selected patients, parallel to routing core needle biopsy assessment, gene expression profile of tumour was analysed by oligonucleotide microarrays. Tumour parameters associated with pCR in univariate analysis were: tumour grade, nuclear grade, mitotic index, Ki67, oestrogen and progesterone receptor (all p |
Document Type: | article |
File Description: | electronic resource |
Language: | English |
ISSN: | 1233-9687 2084-9869 |
Relation: | https://www.termedia.pl/Association-of-breast-cancer-grade-with-response-to-neoadjuvant-chemotherapy-assessed-postoperatively,55,37391,1,1.html; https://doaj.org/toc/1233-9687; https://doaj.org/toc/2084-9869 |
DOI: | 10.5114/pjp.2019.87101 |
Access URL: | https://doaj.org/article/54e543275bb84b828e304162f0be70c2 |
Accession Number: | edsdoj.54e543275bb84b828e304162f0be70c2 |
Database: | Directory of Open Access Journals |
ISSN: | 12339687 20849869 |
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DOI: | 10.5114/pjp.2019.87101 |
Published in: | Polish Journal of Pathology |
Language: | English |