| Title: |
The Association Between Polymorphisms in Cell-Cycle Genes and Mitochondrial DNA Copy Number in Coke Oven Workers |
| Authors: |
Yuping Wang, Jiebing Tan, Wei Wang, Xiaoran Duan, Brooke Lappe, Liuhua Shi, Yongli Yang, Xuezhong Shi |
| Source: |
Frontiers in Public Health, Vol 10 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Public aspects of medicine |
| Subject Terms: |
mitochondrial DNA copy number, coke oven emissions, cell-cycle genes, polymorphisms, generalized linear models (GLM), Public aspects of medicine, RA1-1270 |
| More Details: |
The mitochondrial DNA (mtDNA) copy number is a vital component in maintaining normal mitochondrial function. It is affected by environmental and occupational exposures, as well as polymorphisms in nuclear genes. Nonetheless, the specific roles of polymorphisms in cell-cycle genes and mtDNA copy number are still unknown. This study enrolled a sample of 544 coke oven workers and 238 non-exposed controls so as to assess the effect of exposure of coke oven emissions (COEs) and polymorphisms in cell-cycle genes on the mtDNA copy number. We found that the mtDNA copy number in the exposed group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t =18.931, P < 0.001). The analysis of covariance showed that both the rs1801270 (CA+CC) and the rs1059234 (CT+CC) in p21 gene were associated with lower mtDNA copy number in the exposed group (P = 0.001). Generalized linear models indicated COEs-exposure (β = −0.432, P < 0.001) and rs1059234 (CT+CC) in p21 gene (β = −0.060, P = 0.024) were the factors in mtDNA copy number reduction. In conclusion, this study suggests that the decrease of the mtDNA copy number is associated with COEs-exposure and the rs1059234 (CT+CC) in the p21 gene. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-2565 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fpubh.2022.904856/full; https://doaj.org/toc/2296-2565 |
| DOI: |
10.3389/fpubh.2022.904856 |
| Access URL: |
https://doaj.org/article/54ccd3ddbb9e4318a58ea0b99d2a4fdc |
| Accession Number: |
edsdoj.54ccd3ddbb9e4318a58ea0b99d2a4fdc |
| Database: |
Directory of Open Access Journals |
