Bibliographic Details
| Title: |
Delaying an infliximab infusion by more than 3 days is associated with a significant reduction in trough levels but not with clinical worsening |
| Authors: |
Zohar Ben-Shatach, Tomer Ziv-Baran, Ella Fudim, Miri Yavzori, Orit Picard, Asaf Levartovsky, Limor Selinger, Batia Weiss, Uri Kopylov, Rami Eliakim, Bella Ungar |
| Source: |
Therapeutic Advances in Gastroenterology, Vol 15 (2022) |
| Publisher Information: |
SAGE Publishing, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Background: Higher infliximab trough levels (TLs) correlate with better clinical, inflammatory, and endoscopic outcomes among inflammatory bowel disease (IBD) patients. Although standard scheduled infliximab therapy regimen consists of infusions at pre-defined time-points (weeks 0, 2, 6, and every 8 weeks), short-period deviations from therapeutic schedule are common in ‘real life’, but the pharmacokinetic impact of these deviations has not been explored. In this study, we aim to determine whether short-period deviations from infusion schedule affect infliximab-TL. Methods: A retrospective analysis of all IBD patients receiving infliximab maintenance therapy every 8 weeks was conducted in a tertiary medical center. Patients with anti-drug antibodies, deliberate interval shortening and 59 days since last infusion) was found to significantly affect TL (mean difference in TL 0.9 μg/mL, 95% confidence interval (CI): 0.03–1.9 μg/mL, p 3 days culminate in measurable decrease of TL, although effect on clinical outcome is unclear. This needs to be taken into account when interpreting drug-level test results. Summary: A total of 2088 sera of 302 maintenance period inflammatory bowel disease (IBD) patients treated with infliximab were analyzed, to assess effect of small deviations from infusion schedule on TLs. A significant decline in patients’ trough level (TL) was noted as early as 3 days after scheduled infusion. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1756-2848
17562848 |
| Relation: |
https://doaj.org/toc/1756-2848 |
| DOI: |
10.1177/17562848221083395 |
| Access URL: |
https://doaj.org/article/5485291456cf4c45a2307114ad38611c |
| Accession Number: |
edsdoj.5485291456cf4c45a2307114ad38611c |
| Database: |
Directory of Open Access Journals |
