Bibliographic Details
| Title: |
Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study |
| Authors: |
Gideon Zulu, Dominik Stelzle, Sarah Gabriël, Chiara Trevisan, Inge Van Damme, Chishimba Mubanga, Veronika Schmidt, Bernard J. Ngowi, Tamara M. Welte, Pascal Magnussen, Charlotte Ruether, Agnes Fleury, Pierre Dorny, Emmanuel Bottieau, Isaac K. Phiri, Kabemba E. Mwape, Andrea S. Winkler, the SOLID consortium |
| Source: |
Journal of Epidemiology and Global Health, Vol 14, Iss 3, Pp 1180-1190 (2024) |
| Publisher Information: |
Springer, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Public aspects of medicine |
| Subject Terms: |
Taenia solium, Cysticercosis, Neurocysticercosis, Point-of-care test, Zambia, Prevalence, Public aspects of medicine, RA1-1270 |
| More Details: |
Abstract Background This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia. Methods This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging. Results Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6–27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4–21.1%) in the study population and 38.0% (95% CI 5.2–87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34–11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1–6] versus 2.5 [IQR 1–5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in contrast none of the TS POC CC- participants was diagnosed with active NCC. Conclusion NCC is common in communities in the Eastern province of Zambia, but a large proportion of people remain asymptomatic. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2210-6014 |
| Relation: |
https://doaj.org/toc/2210-6014 |
| DOI: |
10.1007/s44197-024-00271-z |
| Access URL: |
https://doaj.org/article/545fe086fbbc4c2e8f27291997110508 |
| Accession Number: |
edsdoj.545fe086fbbc4c2e8f27291997110508 |
| Database: |
Directory of Open Access Journals |
