Bibliographic Details
| Title: |
High reproducibility of spleen stiffness measurement by vibration‐controlled transient elastography with a spleen‐dedicated module |
| Authors: |
Cristina Rigamonti, Micol Giulia Cittone, Giulia Francesca Manfredi, Andrea Sorge, Riccardo Moia, Andrea Patriarca, Maria Francesca Donato, Gianluca Gaidano, Mario Pirisi, Mirella Fraquelli |
| Source: |
Hepatology Communications, Vol 6, Iss 11, Pp 3006-3014 (2022) |
| Publisher Information: |
Wolters Kluwer Health/LWW, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Abstract Spleen stiffness measurement (SSM) by vibration‐controlled transient elastography (VCTE) is a noninvasive technique for estimating portal hypertension in patients with chronic liver disease (CLD), with its reproducibility yet to be established and its feasibility still unknown beyond CLD. We have studied 420 participants from two tertiary referral centers for liver diseases (Novara, Milan): 297 patients with CLD (32% with cirrhosis) of different etiology (Group A), 63 Philadelphia‐negative myeloproliferative neoplasms (Group B), and 60 heathy volunteers (Group C). All underwent SSM by VCTE with a spleen‐dedicated module (SSM@100 Hz) and liver stiffness measurement (LSM), blindly performed by 2 different operators. In total, 1680 VCTE examinations for SSM were performed (1000 in Novara, 680 in Milan), with an overall 3.2% failure rate. Median SSM was 26.5 kPa (interquartile range [IQR] 20.0–42.3) in Group A, 26.3 kPa (IQR 22.3–33.6) in Group B, and 16.1 kPa (IQR 14.6–18.7) in Group C. In Group A, the median LSM was 6.8 kPa (IQR 4.9–11.3) in Novara and 8.3 kPa (IQR 7.1–10.8) in Milan, the proportion of patients with cirrhosis being 34% in Novara and 31% in Milan. The Group A interobserver agreement ICC was 0.90 (0.88–0.92), significantly lower in the absence of splenomegaly (ICC 0.87 vs. 0.91) and in absence of cirrhosis (ICC 0.84 vs. 0.90); overweight slightly, but not significantly reduced the interobserveragreement. The intra‐observer agreement ICC ranged from 0.91 to 0.96 for the four operators. The Group B interobserver agreement ICC was 0.90 (0.83–0.94). In conclusion, SSM measured by the new spleen‐dedicated VCTE module is a feasible, reliable, and highly reproducible tool in patients with CLD and hematological disorders, and in healthy volunteers. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2471-254X |
| Relation: |
https://doaj.org/toc/2471-254X |
| DOI: |
10.1002/hep4.2070 |
| Access URL: |
https://doaj.org/article/545367aa94f2492293c815b5ba0bac54 |
| Accession Number: |
edsdoj.545367aa94f2492293c815b5ba0bac54 |
| Database: |
Directory of Open Access Journals |
