Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review
| Title: | Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review |
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| Authors: | Ji Young Park, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Hwan Il Kim, Seung Hun Jang, Ki-Suck Jung, Yong Kyun Kim, Hyun Ah Kim, In Jae Lee |
| Source: | The Korean Journal of Internal Medicine, Vol 37, Iss 5, Pp 989-1001 (2022) |
| Publisher Information: | The Korean Association of Internal Medicine, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine |
| Subject Terms: | covid-19, vaccines, drug-related side effects and adverse reactions, pneumonitis, lung diseases, interstitial, Medicine |
| More Details: | Background/Aims Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this study was to report the clinical characteristics of patients with COVID-19 vaccine-related pneumonitis (CV-P) and to review cases reported in the literature. Methods We performed a prospective, observational case series analysis. Results Eleven patients with a median age of 80 years were enrolled. Ten patients developed CV-P after BNT162b2-mRNA vaccination and one after ChAdOx1 nCoV-19 vaccination. We identified various patterns of CV-P, including transient infiltration, life-threatening acute respiratory distress syndrome, and aggravation of underlying interstitial lung disease. Most patients showed favorable outcomes with good responses to corticosteroid therapy. Conclusions Identifying the mechanism of CV-P requires further investigation; however, radiological and laboratory findings in our case series support inflammatory dysregulation in the lung parenchyma after vaccination. Clinicians should consider CV-P in patients with atypical lung infiltration, no specific etiologies, and recent COVID-19 vaccination. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1226-3303 2005-6648 |
| Relation: | http://kjim.org/upload/pdf/kjim-2022-072.pdf; https://doaj.org/toc/1226-3303; https://doaj.org/toc/2005-6648 |
| DOI: | 10.3904/kjim.2022.072 |
| Access URL: | https://doaj.org/article/a541ec2d74aa44278f0b72fb0d0d0dd5 |
| Accession Number: | edsdoj.541ec2d74aa44278f0b72fb0d0d0dd5 |
| Database: | Directory of Open Access Journals |
| ISSN: | 12263303 20056648 |
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| DOI: | 10.3904/kjim.2022.072 |
| Published in: | The Korean Journal of Internal Medicine |
| Language: | English |