Academic Journal
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification
| Title: | Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification |
|---|---|
| Authors: | Maria C. Ferreira dos Santos, Cole P. Anderson, Susanne Neschen, Kimberly B. Zumbrennen-Bullough, Steven J. Romney, Melanie Kahle-Stephan, Birgit Rathkolb, Valerie Gailus-Durner, Helmut Fuchs, Eckhard Wolf, Jan Rozman, Martin Hrabe de Angelis, Weiling Maggie Cai, Malini Rajan, Jennifer Hu, Peter C. Dedon, Elizabeth A. Leibold |
| Source: | Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
| Publisher Information: | Nature Portfolio, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Science |
| Subject Terms: | Science |
| More Details: | Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing and reduced insulin secretion. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-019-14004-5 |
| Access URL: | https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141 |
| Accession Number: | edsdoj.53f26f3f35f1461a9fc51b7c51673141 |
| Database: | Directory of Open Access Journals |
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