Bibliographic Details
| Title: |
Advances in therapeutic agents targeting quiescent cancer cells |
| Authors: |
Wan Najbah Nik Nabil, Zhichao Xi, Mengfan Liu, Yang Li, Mu Yao, Tao Liu, Qihan Dong, Hongxi Xu |
| Source: |
Acta Materia Medica, Vol 1, Iss 1, Pp 56-71 (2022) |
| Publisher Information: |
Compuscript Ltd, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Pharmacy and materia medica
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
quiescence, dormancy, neoplasm, mechanism, therapeutic agent, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Quiescent cancer cells (QCCs) reversibly reside in G0 phase, thus allowing them to survive chemotherapy and radiotherapy, which generally target proliferating cells. Surviving QCCs may re-proliferate, and consequently result in cancer progression, recurrence, and metastasis. Therefore, understanding the key players governing QCC survival and activation is crucial for developing QCC-targeting agents. This review presents an overview of (1) the mechanisms underlying the regulation of QCC status and (2) recent advances in the development of QCC-targeting therapeutic agents and their underlying mechanisms. The development of effective therapeutic modalities that target QCCs may enable new cancer treatments to prevent cancer progression and recurrence. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2737-7946 |
| Relation: |
https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2021-0005; https://doaj.org/toc/2737-7946 |
| DOI: |
10.15212/AMM-2021-0005 |
| Access URL: |
https://doaj.org/article/53e57f2e55724b01b71cd2f753a24ff1 |
| Accession Number: |
edsdoj.53e57f2e55724b01b71cd2f753a24ff1 |
| Database: |
Directory of Open Access Journals |
