Bibliographic Details
| Title: |
Pathophysiology of Swallowing Dysfunction in Parkinson Disease and Lack of Dopaminergic Impact on the Swallow Function and on the Effect of Thickening Agents |
| Authors: |
Weslania Viviane Nascimento, Viridiana Arreola, Pilar Sanz, Ediz Necati, Mireia Bolivar-Prados, Emilia Michou, Omar Ortega, Pere Clavé |
| Source: |
Brain Sciences, Vol 10, Iss 9, p 609 (2020) |
| Publisher Information: |
MDPI AG, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
oropharyngeal dysphagia, Parkinson’s disease, oropharyngeal swallow response, thickening agents, dopamine, shear viscosity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
(1) Background: The effect of dopaminergic treatment on swallowing response in patients with Parkinson’s disease (PD) suffering oropharyngeal dysphagia (OD) is not understood. Aim: To characterize OD pathophysiology in PD and to assess whether dopaminergic states affect swallow function and the effect of thickeners. (2) Methods: Fifty patients with PD (40 evaluated in OFF/ON states) and 12 healthy volunteers (HVs) were evaluated with videofluoroscopy (VFS) to assess the swallowing biomechanics and kinematics of the swallowing response at three different shear-viscosities (p < 0.05). An LVC ≥ 260 ms cutoff predicted unsafe swallow (sensitivity ≥ 0.83, specificity ≥ 0.57, AUC = 0.80) in PD. Increasing bolus viscosity improved deglutition safety but increased oropharyngeal residue. There were no differences in swallowing between the OFF/ON states. (4) Conclusions: In initial PD stages, oropharyngeal swallow response is severely delayed, while mildly impaired swallow safety improves with increasing bolus viscosity, which increases residue. Dopaminergic treatment does not affect swallowing or the therapeutic effect of thickeners. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-3425 |
| Relation: |
https://www.mdpi.com/2076-3425/10/9/609; https://doaj.org/toc/2076-3425 |
| DOI: |
10.3390/brainsci10090609 |
| Access URL: |
https://doaj.org/article/53b734a232d04023bff5f2bc31bacc3d |
| Accession Number: |
edsdoj.53b734a232d04023bff5f2bc31bacc3d |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
