Bibliographic Details
| Title: |
Adhesion pathway proteins and risk of atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis |
| Authors: |
Israel J. Mendez, Sheila M. Manemann, Elizabeth J. Bell, Nicholas B. Larson, Paul A. Decker, Marco A. Guerrero, Naomi Q. Hanson, Susan R. Heckbert, James S. Pankow, Michael Y. Tsai, Suzette J. Bielinski |
| Source: |
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Adhesion molecules, Atrial fibrillation, Inflammation, Risk factors, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Background The cellular adhesion pathway has been suggested as playing an important role in the pathogenesis of atrial fibrillation (AF). However, prior studies that have investigated the role of adhesion pathway proteins in risk of AF have been limited in the number of proteins that were studied and in the ethnic and racial diversity of the study population. Therefore we aimed to study the associations of fifteen adhesion pathway proteins with incident AF in a large, diverse population. Methods Multi-Ethnic Study of Atherosclerosis participants from four races/ethnicities (n = 2504) with protein levels measured were followed for incident AF (n = 253). HGF protein was measured on Exam 1 samples (N = 6669; AF n = 851). Cox proportional hazards regression was used to assess the association of AF with 15 adhesion pathway proteins. Bonferroni correction was applied to account for multiple comparisons. Results After adjusting for potential confounding variables (age, sex, race/ethnicity, height, body mass index, systolic blood pressure, antihypertension therapy, diabetes status, current smoker, current alcohol use, and total and HDL cholesterol), and accounting for multiple testing (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2261 |
| Relation: |
https://doaj.org/toc/1471-2261 |
| DOI: |
10.1186/s12872-021-02241-w |
| Access URL: |
https://doaj.org/article/536e2678a45c4615b11574d208a14666 |
| Accession Number: |
edsdoj.536e2678a45c4615b11574d208a14666 |
| Database: |
Directory of Open Access Journals |
