Bibliographic Details
| Title: |
Trained Immunity-Based Vaccine in B Cell Hematological Malignancies With Recurrent Infections: A New Therapeutic Approach |
| Authors: |
Juliana Ochoa-Grullón, Celina Benavente Cuesta, Ataúlfo González Fernández, Gustavo Cordero Torres, Cristina Pérez López, Ascensión Peña Cortijo, Laura Conejero Hall, Marta Mateo Morales, Antonia Rodríguez de la Peña, Carmen M. Díez-Rivero, Edgard Rodríguez de Frías, Kissy Guevara-Hoyer, Miguel Fernández-Arquero, Silvia Sánchez-Ramón |
| Source: |
Frontiers in Immunology, Vol 11 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
hematological malignancies, IgA, recurrent respiratory tract infections, trained immunity-based vaccines, MV130, prophylaxis, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Infectious complications are a major cause of morbidity and mortality in B-cell hematological malignancies (HM). Prophylaxis for recurrent infections in HM patients with antibody deficiency consists of first-line antibiotics and when unsuccessful, gammaglobulin replacement therapy (IgRT). Recent knowledge of trained immunity-based vaccines (TIbV), such as the sublingual polybacterial formulation MV130, has shown a promising strategy in the management of patients with recurrent infections. We sought to determine the clinical benefit of MV130 in a cohort of HM patients with recurrent respiratory tract infections (RRTIs) who underwent immunization with MV130 for 3 months. Clinical information included the frequency of infections, antibiotic use, number of visits to the GP and hospitalizations previous and after MV130 immunotherapy. Improvement on infection rate was classified as: clear (>60% reduction of infection), partial (26%–60%) and low (≤25%) improvement. Fifteen HM patients (aged 42 to 80 years; nine females) were included in the study. All patients reduced their infection rate. Analysis of paired data revealed that the median (range, min - max) of respiratory infectious rate significantly decreased from 4.0 (8.0–3.0) to 2.0 (4.0–0.0) (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.611566/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2020.611566 |
| Access URL: |
https://doaj.org/article/53578e113715410f8fad7a3f5a83abb6 |
| Accession Number: |
edsdoj.53578e113715410f8fad7a3f5a83abb6 |
| Database: |
Directory of Open Access Journals |
