Academic Journal
RETRACTED ARTICLE: A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair
| Title: | RETRACTED ARTICLE: A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair |
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| Authors: | Lanlan Dong, Can Huang, Baohua Zhao, Guangyun Hu, Yong Huang, Xiaorong Zhang, Xiaohong Hu, Ying Wang, XiaoyanSun, Wei Qian, Gaoxing Luo |
| Source: | Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-20 (2023) |
| Publisher Information: | BMC, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Chronic wound healing, Multidrug-resistant bacterial infection, Hydrogel, Anti-infection, Anti-inflammatory, PMB, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract Suppressing persistent multidrug-resistant (MDR) bacterial infections and excessive inflammation is the key for treating chronic wounds. Therefore, developing a microenvironment-responsive material with good biodegradability, drug-loading, anti-infection, and anti-inflammatory properties is desired to boost the chronic wounds healing process; however, using ordinary assembly remains a defect. Herein, we propose a pH/enzyme dual-responsive polymyxin B (PMB) spatiotemporal-release hydrogel (GelMA/OSSA/PMB), namely, the amount of OSSA and PMB released from GelMA/OSSA/PMB was closely related the wound pH and the enzyme concentration changing. The GelMA/OSSA/PMB showed better biosafety than equivalent free PMB, owing to the controlled release of PMB, which helped kill planktonic bacteria and inhibit biofilm activity in vitro. In addition, the GelMA/OSSA/PMB exhibited excellent antibacterial and anti-inflammatory properties. A MDR Pseudomonas aeruginosa caused infection was effectively resolved by the GelMA/OSSA/PMB hydrogel in vivo, thereby significantly boosting wound closure during the inflammatory phase. Furthermore, GelMA/OSSA/PMB accelerated the sequential phases of wound repair. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-023-01947-7 |
| Access URL: | https://doaj.org/article/52fc4ab4b89143d0b5d99778d4d58913 |
| Accession Number: | edsdoj.52fc4ab4b89143d0b5d99778d4d58913 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14773155 |
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| DOI: | 10.1186/s12951-023-01947-7 |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |