Bibliographic Details
| Title: |
Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures |
| Authors: |
Thomas Kammertoens, Sarah Jeuthe, Heike Baranzke, Antonina Klippert, Christa Thöne-Reineke |
| Source: |
Animals, Vol 11, Iss 6, p 1789 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Veterinary medicine
LCC:Zoology |
| Subject Terms: |
immunodeficiency, severity assessment, animal experiment, 3R, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| More Details: |
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods are available. However, the breeding of immunodeficient mice is considered an experiment requiring a permit, even if no pain, suffering or harm is observed under scientifically required defined hygienic housing conditions, as determined by established methods of severity assessment. This seems contradictory and leads to uncertainty among scientists. With this commentary, we would like to shed light on this topic from different perspectives and propose a solution in terms of individualized severity assessment and approval procedures. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-2615 |
| Relation: |
https://www.mdpi.com/2076-2615/11/6/1789; https://doaj.org/toc/2076-2615 |
| DOI: |
10.3390/ani11061789 |
| Access URL: |
https://doaj.org/article/52f96241ea8640d1979bbe32575b33c9 |
| Accession Number: |
edsdoj.52f96241ea8640d1979bbe32575b33c9 |
| Database: |
Directory of Open Access Journals |
