Bibliographic Details
| Title: |
Identification of immune cell infiltration and effective biomarkers of polycystic ovary syndrome by bioinformatics analysis |
| Authors: |
Mengge Gao, Xiaohua Liu, Mengxuan Du, Heng Gu, Hang Xu, Xingming Zhong |
| Source: |
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-11 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Gynecology and obstetrics |
| Subject Terms: |
Polycystic ovary syndrome, Immune cell infiltration, Biomarker, Single-sample gene set enrichment analysis, Gynecology and obstetrics, RG1-991 |
| More Details: |
Abstract Background Patients with polycystic ovary syndrome (PCOS) exhibit a chronic inflammatory state, which is often accompanied by immune, endocrine, and metabolic disorders. Clarification of the pathogenesis of PCOS and exploration of specific biomarkers from the perspective of immunology by evaluating the local infiltration of immune cells in the follicular microenvironment may provide critical insights into disease pathogenesis. Methods In this study, we evaluated immune cell subsets and gene expression in patients with PCOS using data from the Gene Expression Omnibus database and single-sample gene set enrichment analysis. Results In total, 325 differentially expressed genes were identified, among which TMEM54 and PLCG2 (area under the curve = 0.922) were identified as PCOS biomarkers. Immune cell infiltration analysis showed that central memory CD4+ T cells, central memory CD8+ T cells, effector memory CD4+ T cells, γδ T cells, and type 17 T helper cells may affect the occurrence of PCOS. In addition, PLCG2 was highly correlated with γδ T cells and central memory CD4+ T cells. Conclusions Overall, TMEM54 and PLCG2 were identified as potential PCOS biomarkers by bioinformatics analysis. These findings established a basis for further exploration of the immunological mechanisms of PCOS and the identification of therapeutic targets. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2393 |
| Relation: |
https://doaj.org/toc/1471-2393 |
| DOI: |
10.1186/s12884-023-05693-4 |
| Access URL: |
https://doaj.org/article/52f8891237f64c6cab972457888b19c1 |
| Accession Number: |
edsdoj.52f8891237f64c6cab972457888b19c1 |
| Database: |
Directory of Open Access Journals |
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