QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score
| Title: | QTc prolongation and diastolic dysfunction in cirrhosis patients with higher Child-Pugh score |
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| Authors: | Chandrakant Salve, Jaiprakash Kuldeep, Dinesh Singh Mahor |
| Source: | Asian Journal of Medical Sciences, Vol 14, Iss 10, Pp 227-234 (2023) |
| Publisher Information: | Manipal College of Medical Sciences, Pokhara, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine |
| Subject Terms: | child–pugh score, cirrhosis, cirrhotic cardiomyopathy, diastolic dysfunction, qtc interval, Medicine |
| More Details: | Background: Cirrhosis is associated with numerous cardiac abnormalities, which include increased cardiac output, left ventricular diastolic dysfunction, increased wall thickness of cardiac chambers, and pulmonary arterial hypertension. Without further identified cardiac disorders, cirrhotic cardiomyopathy (CCM) is a chronic cardiac dysfunction with an impaired contractile reaction to stress stimuli, impeded diastolic relaxation, and electrophysiological anomalies with a prolonged QT interval. In chronic hepatic disease, echocardiography is a non-invasive method for detecting CCM. Aims and Objectives: The focus was to examine the link between cardiac dysfunction and conduction disturbances in cirrhosis individuals and the extent of the disorder. Materials and Methods: A case–control investigation was conducted at a Medical College. The research involved a cohort of 50 patients and an equal number of 50 healthy controls. The Child-Pugh (CP) Score was utilized to evaluate the degree of liver cirrhosis severity. Bazett’s formula was utilized to compute the QTc interval. The 2D echocardiography revealed the presence of diastolic dysfunction, as evidenced by the E/A ratio. Results: Of 50 patients, 37 (74%) were male, 13 (26%) were female, and the mean age of the patients was 51.76±9.89 years. The E/A ratio in the control group had a mean value of 1.10±0.19, whereas in the cases, it had a mean value of 0.94±0.20. A statistically significant relationship was observed between the control and cases, with a P-value of less than 0.0001. QTc interval between control with a mean value of 382.9±47.34 ms and cases with a mean value of 431.6±62.84 ms was found statistically significant with P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2467-9100 2091-0576 |
| Relation: | https://www.nepjol.info/index.php/AJMS/article/view/54794; https://doaj.org/toc/2467-9100; https://doaj.org/toc/2091-0576 |
| DOI: | 10.3126/ajms.v14i10.54794 |
| Access URL: | https://doaj.org/article/c52d2b5423aa4e8098a84356208bc226 |
| Accession Number: | edsdoj.52d2b5423aa4e8098a84356208bc226 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24679100 20910576 |
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| DOI: | 10.3126/ajms.v14i10.54794 |
| Published in: | Asian Journal of Medical Sciences |
| Language: | English |