Annona crassiflora Mart. Fruit Peel Polyphenols Preserve Cardiac Antioxidant Defense and Reduce Oxidative Damage in Hyperlipidemic Mice
| Title: | Annona crassiflora Mart. Fruit Peel Polyphenols Preserve Cardiac Antioxidant Defense and Reduce Oxidative Damage in Hyperlipidemic Mice |
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| Authors: | Eliana Akemi Komino, Letícia Pereira Afonso Ramos, Adriele Vieira de Souza, Douglas Carvalho Caixeta, Vinicius Prado Bittar, Ana Luiza Borges, Françoise Vasconcelos Botelho, Foued Salmen Espindola, Allisson Benatti Justino |
| Source: | Foods, Vol 12, Iss 11, p 2097 (2023) |
| Publisher Information: | MDPI AG, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Chemical technology |
| Subject Terms: | araticum, cardiovascular disease, dyslipidemia, glutathione defense, oxidative stress, Chemical technology, TP1-1185 |
| More Details: | Dyslipidemia and oxidative stress are directly related to the pathogenesis of cardiovascular diseases. Annona crassiflora Mart. (ACM) has been traditionally used in folk medicine to alleviate inflammation and pain. This plant is rich in polyphenols, which exhibit high antioxidant capacity. The present study aimed to elucidate the antioxidant properties of ACM in the heart of hyperlipidemic mice. The animals were orally administered either a crude ethanol extract (CEAc) or a polyphenols-rich fraction (PFAc) obtained from ACM fruit peel. There were correlations between blood and fecal biochemical data with cardiac oxidative stress biomarkers. Here, the pre-treatment with CEAc for 12 d led to an increase in glutathione content (GSH) and a reduction in the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase. Moreover, PFAc was found to enhance the total antioxidant capacity as well as GSH, SOD and CAT activities, which were reduced by Triton WR-1339-induced hyperlipidemia. Moreover, the administration of PFAc before the treatment resulted in a decrease in protein carbonylation and lipid peroxidation levels, as well as a reduction in the activities of glutathione reductase and glucose-6-phosphate dehydrogenase. ACM fruit peel showed improvement in the glutathione system, mainly its polyphenols-rich fraction, indicating a potential cardioprotective antioxidant usage of this plant extract. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 12112097 2304-8158 |
| Relation: | https://www.mdpi.com/2304-8158/12/11/2097; https://doaj.org/toc/2304-8158 |
| DOI: | 10.3390/foods12112097 |
| Access URL: | https://doaj.org/article/d5263d9b5ade48e5893c5a7a0edd34a4 |
| Accession Number: | edsdoj.5263d9b5ade48e5893c5a7a0edd34a4 |
| Database: | Directory of Open Access Journals |
| ISSN: | 12112097 23048158 |
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| DOI: | 10.3390/foods12112097 |
| Published in: | Foods |
| Language: | English |