| Title: |
Anticancer Photodynamic and Non-photodynamic Effects of Pterin Derivatives on a Pancreatic Cancer Cell Line |
| Authors: |
Takashi Miyoshi, Toshiyuki Arai, Mitsuru Nonogawa, Keisuke Makino, Hiroko Mori, Kouhei Yamashita, Masataka Sasada |
| Source: |
Journal of Pharmacological Sciences, Vol 107, Iss 2, Pp 221-225 (2008) |
| Publisher Information: |
Elsevier, 2008. |
| Publication Year: |
2008 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
Therapeutics. Pharmacology, RM1-950 |
| More Details: |
To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP. Keywords:: pterin derivative, anticancer drug, photodynamic effect |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1347-8613 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1347861319314409; https://doaj.org/toc/1347-8613 |
| DOI: |
10.1254/jphs.08002SC |
| Access URL: |
https://doaj.org/article/51f9e9a12af64c97b680aac0bbdbb720 |
| Accession Number: |
edsdoj.51f9e9a12af64c97b680aac0bbdbb720 |
| Database: |
Directory of Open Access Journals |
