Bibliographic Details
| Title: |
Internal tissue references for 18Fluorodeoxyglucose vascular inflammation imaging: Implications for cardiovascular risk stratification and clinical trials. |
| Authors: |
Mark A Ahlman, Davis M Vigneault, Veit Sandfort, Roberto Maass-Moreno, Jenny Dave, Ahmed Sadek, Marissa B Mallek, Mariana A F Selwaness, Peter Herscovitch, Nehal N Mehta, David A Bluemke |
| Source: |
PLoS ONE, Vol 12, Iss 11, p e0187995 (2017) |
| Publisher Information: |
Public Library of Science (PLoS), 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
INTRODUCTION:18Fluorodeoxyglucose (FDG) positron emission tomography (PET) uptake in the artery wall correlates with active inflammation. However, in part due to the low spatial resolution of PET, variation in the apparent arterial wall signal may be influenced by variation in blood FDG activity that cannot be fully corrected for using typical normalization strategies. The purpose of this study was to evaluate the ability of the current common methods to normalize for blood activity and to investigate alternative methods for more accurate quantification of vascular inflammation. MATERIALS AND METHODS:The relationship between maximum FDG aorta wall activity and mean blood activity was evaluated in 37 prospectively enrolled subjects aged 55 years or more, treated for hyperlipidemia. Target maximum aorta standardized uptake value (SUV) and mean background reference tissue activity (blood, spleen, liver) were recorded. Target-to-background ratios (TBR) and arterial maximum activity minus blood activity were calculated. Multivariable regression was conducted, predicting uptake values based on variation in background reference and target tissue FDG uptake; adjusting for gender, age, lean body mass (LBM), blood glucose, blood pool activity, and glomerular filtration rate (GFR), where appropriate. RESULTS:Blood pool activity was positively associated with maximum artery wall SUV (β = 5.61, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC5683610?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0187995 |
| Access URL: |
https://doaj.org/article/ec51e24d027d400cbc9f72a0a797a73c |
| Accession Number: |
edsdoj.51e24d027d400cbc9f72a0a797a73c |
| Database: |
Directory of Open Access Journals |
