Academic Journal
Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells.
| Title: | Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells. |
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| Authors: | Olivia Munoz, Riddhima Banga, Rachel Schelling, Francesco Andrea Procopio, Andrea Mastrangelo, Pauline Nortier, Khalid Ohmiti, Jean Daraspe, Matthias Cavassini, Craig Fenwick, Laurent Perez, Matthieu Perreau |
| Source: | PLoS Pathogens, Vol 18, Iss 7, p e1010673 (2022) |
| Publisher Information: | Public Library of Science (PLoS), 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| Subject Terms: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| More Details: | The limited development of broadly neutralizing antibodies (BnAbs) during HIV infection is classically attributed to an inadequate B-cell help brought by functionally impaired T follicular helper (Tfh) cells. However, the determinants of Tfh-cell functional impairment and the signals contributing to this condition remain elusive. In the present study, we showed that PD-L1 is incorporated within HIV virions through an active mechanism involving p17 HIV matrix protein. We subsequently showed that in vitro produced PD-L1high but not PD-L1low HIV virions, significantly reduced Tfh-cell proliferation and IL-21 production, ultimately leading to a decreased of IgG1 secretion from GC B cells. Interestingly, Tfh-cell functions were fully restored in presence of anti-PD-L1/2 blocking mAbs treatment, demonstrating that the incorporated PD-L1 proteins were functionally active. Taken together, the present study unveils an immunovirological mechanism by which HIV specifically exploits the regulatory potential of PD-L1 to suppress the immune system during the course of HIV infection. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1553-7366 1553-7374 |
| Relation: | https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.1010673 |
| Access URL: | https://doaj.org/article/d51ad57404624efcbb0d0e6a151e75ef |
| Accession Number: | edsdoj.51ad57404624efcbb0d0e6a151e75ef |
| Database: | Directory of Open Access Journals |
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| ISSN: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1010673 |
| Published in: | PLoS Pathogens |
| Language: | English |