Bibliographic Details
| Title: |
Unveiling the contribution of tumor-associated macrophages in driving epithelial-mesenchymal transition: a review of mechanisms and therapeutic Strategies |
| Authors: |
Yijia Zhang, Xiaofei Ding, Xue Zhang, Ye Li, Rui Xu, Hai-Jun Li, Daiying Zuo, Guang Chen |
| Source: |
Frontiers in Pharmacology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
TAM, tumor associated macrophage, TME, tumor microenvironment, EMT, epithelialmesenchymal transition, ECM, extracellular matrix, CSF1R, colony-stimulating factor 1 receptor, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Tumor-associated macrophages (TAMs), fundamental constituents of the tumor microenvironment (TME), significantly influence cancer development, primarily by promoting epithelial-mesenchymal transition (EMT). EMT endows cancer cells with increased motility, invasiveness, and resistance to therapies, marking a pivotal juncture in cancer progression. The review begins with a detailed exposition on the origins of TAMs and their functional heterogeneity, providing a foundational understanding of TAM characteristics. Next, it delves into the specific molecular mechanisms through which TAMs induce EMT, including cytokines, chemokines and stromal cross-talking. Following this, the review explores TAM-induced EMT features in select cancer types with notable EMT characteristics, highlighting recent insights and the impact of TAMs on cancer progression. Finally, the review concludes with a discussion of potential therapeutic targets and strategies aimed at mitigating TAM infiltration and disrupting the EMT signaling network, thereby underscoring the potential of emerging treatments to combat TAM-mediated EMT in cancer. This comprehensive analysis reaffirms the necessity for continued exploration into TAMs’ regulatory roles within cancer biology to refine therapeutic approaches and improve patient outcomes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-9812 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphar.2024.1404687/full; https://doaj.org/toc/1663-9812 |
| DOI: |
10.3389/fphar.2024.1404687 |
| Access URL: |
https://doaj.org/article/5181cfe6c6524cf78497e78f84773d76 |
| Accession Number: |
edsdoj.5181cfe6c6524cf78497e78f84773d76 |
| Database: |
Directory of Open Access Journals |
