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Kévin Jean,1– 3 Ahmed Tawheed,4 Liem Binh Luong Nguyen,5 Tarek Heikal,6 Usama Eldaly,6 Neveen Gaber Elhadidy,7 Ahmed Elghaieb,8 Ahmed Aboudonia,8 Laura Tondeur,5 Amélie Dublineau,5 Arnaud Fontanet,2,5 Mohamed El-Kassas4,9 1Laboratoire MESuRS, Conservatoire national des arts et métiers, Paris, France; 2Unité PACRI, Institut Pasteur & Conservatoire national des arts et métiers, Paris, France; 3IBENS, École Normale Supérieure, CNRS, INSERM, Université Paris Science & Lettres, Paris, France; 4Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt; 5Emerging Diseases Epidemiology Unit, Institut Pasteur, Université Paris-Cité, Paris, France; 6Medical Oncology Department, Damietta Oncology Center, Damietta, Egypt; 7Pharmaceutical Services Department, Damietta Oncology Center, Damietta, Egypt; 8Radiology Department, Damietta Oncology Center, Damietta, Egypt; 9Clinical Research Centre, Air Force Specialized Hospital, Cairo, EgyptCorrespondence: Kévin Jean, Laboratoire MESuRS, Conservatoire national des arts et métiers, 292 Rue Saint Martin, Paris, 75003, France, Email kevin.jean@lecnam.netContext: The difference in prognosis between patients diagnosed with viral versus non-viral hepatocellular carcinoma (HCC) in Egypt remains unclear.Methods: We used data from patients diagnosed with HCC between 2007 and 2019 from a large monocentric retrospective cohort at the Damietta Oncology referral center (northern Egypt). Presentation and treatment were compared between viral versus non-viral etiology HCC patients. Survival was compared relying on univariate and multivariate Cox regressions.Results: Data from 4714 HCC patients were analyzed. Among them, 204 (4.3%) presented with a non-viral etiology. Patients with non-viral versus viral etiology had a similar presentation overall, especially regarding the BCLC stage at HCC diagnosis. After controlling for various individual characteristics, patients with non-viral versus viral etiology had poorer survival (adjusted Hazard Ratio: 1.244; 95% Confidence Interval: 1.069– 1.447).Conclusion: Despite similar features, patients with non-viral- related HCC had poorer survival compared to patients with viral-related HCC.Keywords: hepatocellular carcinoma, liver cancer, viral etiology, non-viral etiology, survival, epidemiology |
