Bibliographic Details
| Title: |
Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis |
| Authors: |
LIU Yandong, DENG Qiang, ZHANG Yanjun, LI Zhongfeng, PENG Randong, GUO Tiefeng, WANG Yurong, CHEN Bo |
| Source: |
Xiehe Yixue Zazhi, Vol 15, Iss 1, Pp 147-152 (2024) |
| Publisher Information: |
Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
myoblast, osteogenesis, signal pathway, osteosarcopenia, Medicine |
| More Details: |
Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass, damage to bone tissue microstructure, increased bone fragility, and susceptibility to fractures, while sarcopenia is a syndrome characterized by progressive reduction in overall muscle mass and functional decline. Based on the common pathophysiological mechanism and close correlation between the two, the concept of 'osteosarcopenia' has gradually emerged to describe the simultaneous attenuation of muscles and bones. Signaling pathways serve as important signal transmission channels between muscles and bones, and if abnormal, they can lead to osteosarcopenia. The aim of this article, therefore, is to review the signaling pathways related to osteogenesis and myogenesis, such as Hedgehog, Hippo, mTOR, MAPK, in order to provide new ideas for targeted treatment of osteosarcopenia. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
1674-9081 |
| Relation: |
https://doaj.org/toc/1674-9081 |
| DOI: |
10.12290/xhyxzz.2023-0277 |
| Access URL: |
https://doaj.org/article/512b874706f84481b79d677196fc0ba0 |
| Accession Number: |
edsdoj.512b874706f84481b79d677196fc0ba0 |
| Database: |
Directory of Open Access Journals |
