Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial
| Title: | Antidepressant Effect of Asperugo procumbens L. in Comparison with Fluoxetine: a Randomized Double Blind Clinical Trial |
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| Authors: | Mehran Zarghami, Aroona Chabra, Mohammad Azadbakht, Alireza Khalilian, Ali Asghar Hoseini |
| Source: | Research Journal of Pharmacognosy, Vol 5, Iss 3, Pp 15-20 (2018) |
| Publisher Information: | Iranian Society of Pharmacognosy, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Pharmacy and materia medica |
| Subject Terms: | Asperugo procumbens, badranjbuyeh, Depression, fluoxetine, Pharmacy and materia medica, RS1-441 |
| More Details: | Background and objectives: Aseprugo procumbens is used as antianxety and depression in Iranian traditional medicine; however no clinical trial has been performed about these properties. The aim of this study was to evaluate the antidepressant efficacy and safety of hydroalcoholic extract of A. procumbens. Methods: In this double blind study, 30 outpatients with mild to moderate depressive disorder (according to DMS-IV-TR criteria who had a score of 18-25 on the Hamilton Depression Rating Scale (HDRS) were randomly divided in two group, 1) received 10 mg fluoxetine capsule, 2) received 1.2 g dried extract of A. procumbens capsule (6 mg flavonoid,) orally per day. Patients were followed up for 6 weeks; the recovery process was assessed by the HDRS in weeks 0, 2, 4 and 6. Results: A significant decrease in HDRS was observed in both groups after the fourth week. After the sixth week, fluoxetine had a greater anti-depressant activity than A. procumbens (p value =0.03). There were no significant differences in terms of adverse effects in both groups. Conclusions: The hydroalcoholic extract of A. procumbens can be considered as an effective and safe remedy for mild to moderate depressive disorder. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2345-4458 2345-5977 |
| Relation: | http://www.rjpharmacognosy.ir/article_64860_3f60b43d8238c9a451f59d5fa6d87dd9.pdf; https://doaj.org/toc/2345-4458; https://doaj.org/toc/2345-5977 |
| DOI: | 10.22127/rjp.2018.64860 |
| Access URL: | https://doaj.org/article/507c0663638f43829ed0da88f50edfcd |
| Accession Number: | edsdoj.507c0663638f43829ed0da88f50edfcd |
| Database: | Directory of Open Access Journals |
| ISSN: | 23454458 23455977 |
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| DOI: | 10.22127/rjp.2018.64860 |
| Published in: | Research Journal of Pharmacognosy |
| Language: | English |