Bibliographic Details
| Title: |
Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D |
| Authors: |
Alex Hatzimanolis, Sarah Tosato, Mirella Ruggeri, Doriana Cristofalo, Leonidas Mantonakis, Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Mirjana Selakovic, Stefania Foteli, Ioannis Kosteletos, Ilias Vlachos, Rigas-Filippos Soldatos, Nikos Nianiakas, Irene Ralli, Konstantinos Kollias, Angeliki-Aikaterini Ntigrintaki, Pentagiotissa Stefanatou, Robin M. Murray, Evangelos Vassos, Nikos C. Stefanis |
| Source: |
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024) |
| Publisher Information: |
Nature Publishing Group, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Abstract Insufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related alterations in lifestyle habits. Lower vitamin D has also been associated with adverse neurodevelopmental outcomes and predominant negative psychotic symptoms. This study aimed to investigate the contribution of polygenic risk score for circulating 25-hydroxyvitamin D concentration (PRS-vitD) to symptom presentation among individuals with FEP enrolled in the Athens First-Episode Psychosis Research Study (AthensFEP n = 205) and the Psychosis Incident Cohort Outcome Study (PICOS n = 123). The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale at baseline and follow-up assessments (AthensFEP: 4-weeks follow-up, PICOS: 1-year follow-up). Premorbid intelligence and adjustment domains were also examined as proxy measures of neurodevelopmental deviations. An inverse association between PRS-vitD and severity of negative symptoms, in particular lack of social motivation, was detected in the AthensFEP at baseline (adjusted R 2 = 0.04, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2158-3188 |
| Relation: |
https://doaj.org/toc/2158-3188 |
| DOI: |
10.1038/s41398-024-02750-0 |
| Access URL: |
https://doaj.org/article/4f0cc42bf6bd41188fa076dfa5bfa1be |
| Accession Number: |
edsdoj.4f0cc42bf6bd41188fa076dfa5bfa1be |
| Database: |
Directory of Open Access Journals |
