Bibliographic Details
| Title: |
Comparison of characteristics and laboratory tests of COVID-19 hematological patients from France and Brazil during the pre-vaccination period: identification of prognostic profiles for survival |
| Authors: |
Lilith Faucheux, Lucas Bassolli de Oliveira Alves, Sylvie Chevret, Vanderson Rocha |
| Source: |
Hematology, Transfusion and Cell Therapy, Vol 45, Iss 3, Pp 306-316 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: |
Hematology, Covid-19, Prognostic classification, Semi-supervised learning, Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: |
Introduction: COVID-19 disease presentation is heterogeneous, from asymptomatic up to severe life-threatening forms. Getting further insights into patients with specific diseases is of particular interest. We aimed to identify profiles of hematology patients hospitalized with COVID-19 that would be associated with survival and to assess the differences between cohorts Methods: A binational cohort of 263 patients with COVID-19 and hematological disease was studied in Paris, France and São Paulo, Brazil. Patient profiles were based on age, comorbidities, biological measurements, COVID-19 symptoms and hematological disease characteristics. A semi-supervised learning method with a survival endpoint was first used, following which, a classifier was identified to allow the classification of patients using only baseline information Main results: Two profiles of patients were identified, one being young patients with few comorbidities and low C-reactive protein (CRP), D-dimers, lactate dehydrogenase (LDH) and creatinine levels, and the other, older patients, with several comorbidities and high levels of the 4 biology markers. The profiles were strongly associated with survival (p < 0.0001), even after adjusting for age (p = 0.0002). The 30-day survival rate was 77.1% in the first profiles, versus 46.7% in the second. The Brazilian analysis emphasized the importance of age, while the French focused on the comorbidities Conclusion: This analysis showed the importance of CRP, LHD and creatinine in the COVID-19 presentation and prognosis, whatever the geographic origin of the patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2531-1379 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2531137922000840; https://doaj.org/toc/2531-1379 |
| DOI: |
10.1016/j.htct.2022.05.003 |
| Access URL: |
https://doaj.org/article/4f05a3fb4ad0480cb2a4240899c6a4f4 |
| Accession Number: |
edsdoj.4f05a3fb4ad0480cb2a4240899c6a4f4 |
| Database: |
Directory of Open Access Journals |
