Academic Journal
Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea
| Title: | Suppression of lipopolysaccharide-induced COX-2 expression via p38MAPK, JNK, and C/EBPβ phosphorylation inhibition by furomagydarin A, a benzofuran glycoside from Magydaris pastinacea |
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| Authors: | Shiu-Wen Huang, Ming Jen Hsu, Hsiu-Chen Chen, Rita Meleddu, Simona Distinto, Elias Maccioni, Filippo Cottiglia |
| Source: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | COX-2, benzofurans, Magydaris pastinacea, p38MAPK, JNK, C/EBPβ, Therapeutics. Pharmacology, RM1-950 |
| More Details: | The phytochemical investigation of the methanol extract of the seeds of Magydaris pastinacea afforded two undescribed benzofuran glycosides, furomagydarins A-B (1, 2), together with three known coumarins. The structures of the new isolates were elucidated after extensive 1D and 2D NMR experiments as well as HR MS. Compound 1 was able to inhibit the COX-2 expression in RAW264.7 macrophages exposed to lipopolysaccharide, a pro-inflammatory stimulus. RT-qPCR and luciferase reporter assays suggested that compound 1 reduces COX-2 expression at the transcriptional level. Further studies highlighted the capability of compound 1 to suppress the LPS-induced p38MAPK, JNK, and C/EBPβ phosphorylation, leading to COX-2 down-regulation in RAW264.7 macrophages. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14756366 1475-6374 1475-6366 |
| Relation: | https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374 |
| DOI: | 10.1080/14756366.2023.2287420 |
| Access URL: | https://doaj.org/article/4ede0bc6e01e44d398ce55962401b995 |
| Accession Number: | edsdoj.4ede0bc6e01e44d398ce55962401b995 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14756366 14756374 |
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| DOI: | 10.1080/14756366.2023.2287420 |
| Published in: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Language: | English |