Academic Journal
An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft
| Title: | An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft |
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| Authors: | Eric K. W. Poon, Masafumi Ono, Xinlei Wu, Jouke Dijkstra, Yu Sato, Matthew Kutyna, Ryo Torii, Johan H. C. Reiber, Christos V. Bourantas, Peter Barlis, Mohammed S. El-Kurdi, Martijn Cox, Renu Virmani, Yoshinobu Onuma, Patrick W. Serruys |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Endothelial shear stress (ESS) plays a key role in the clinical outcomes in native and stented segments; however, their implications in bypass grafts and especially in a synthetic biorestorative coronary artery bypass graft are yet unclear. This report aims to examine the interplay between ESS and the morphological alterations of a biorestorative coronary bypass graft in an animal model. Computational fluid dynamics (CFD) simulation derived from the fusion of angiography and optical coherence tomography (OCT) imaging was used to reconstruct data on the luminal anatomy of a bioresorbable coronary bypass graft with an endoluminal “flap” identified during OCT acquisition. The “flap” compromised the smooth lumen surface and considerably disturbed the local flow, leading to abnormally low ESS and high oscillatory shear stress (OSI) in the vicinity of the “flap”. In the presence of the catheter, the flow is more stable (median OSI 0.02384 versus 0.02635, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-29573-1 |
| Access URL: | https://doaj.org/article/4eba498b400e4425a9ad023f24f0e046 |
| Accession Number: | edsdoj.4eba498b400e4425a9ad023f24f0e046 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-023-29573-1 |
| Published in: | Scientific Reports |
| Language: | English |