Bibliographic Details
| Title: |
Optimizing Antiretroviral Therapy in Heavily ART-Experienced Patients with Multi-Class Resistant HIV-1 Using Proviral DNA Genotypic Resistance Testing |
| Authors: |
Dominic Rauschning, Ira Ehren, Eva Heger, Elena Knops, Gerd Fätkenheuer, Isabelle Suárez, Clara Lehmann |
| Source: |
Viruses, Vol 15, Iss 7, p 1444 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
HIV infection, multi-class resistance, antiretroviral therapy, therapy adjustment, diagnostic tests, resistance testing, Microbiology, QR1-502 |
| More Details: |
Resistance to multiple antiretroviral drugs among people living with HIV (PLWH) can result in a high pill burden, causing toxicity and drug interactions. Thus, the goal is to simplify treatment regimens while maintaining effectiveness. However, former resistance analysis data may not be current or complete. The use of proviral DNA genotyping may assist in selecting appropriate treatment options. A retrospective study was carried out on individuals belonging to the Cologne HIV cohort with a resistance history to two or more antiretroviral (ARV) classes and on non-standard antiretroviral therapy (ART). Patients required former viral RNA and a recent proviral DNA resistance test to be available prior to the switch to ART. Potential discrepancies between resistance test results obtained through RNA and proviral DNA methods and the consequent virological and clinical outcomes following ART adjustments were analyzed. Out of 1250 patients, 35 were eligible for inclusion in this study. The median length of known HIV infection was 27 years, and the median duration of ART was 22 years. Of the 35 participants, 16 had received all five ARV classes. Based on proviral DNA genotyping results, ART was simplified in 17 patients. At the last follow-up examination after changing therapy, 15 patients had HIV RNA |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/15/7/1444; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v15071444 |
| Access URL: |
https://doaj.org/article/a4e6989580094838a284adc2091f9798 |
| Accession Number: |
edsdoj.4e6989580094838a284adc2091f9798 |
| Database: |
Directory of Open Access Journals |
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