Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis
| Title: | Antimicrobial effectiveness of maleimides on fungal strains isolated from onychomycosis |
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| Authors: | Carla Wanderley Gayoso, Edeltrudes de Oliveira Lima, Evandro Leite de Souza, Valdir Cechinel Filho, Vinícius Nogueira Trajano, Fillipe de Oliveira Pereira, Igara Oliveira Lima |
| Source: | Brazilian Archives of Biology and Technology, Vol 49, Iss 4, Pp 661-664 (2006) |
| Publisher Information: | Instituto de Tecnologia do Paraná (Tecpar), 2006. |
| Publication Year: | 2006 |
| Collection: | LCC:Biotechnology |
| Subject Terms: | Onychomycosis, fungi, maleimides, antifungical activity, Biotechnology, TP248.13-248.65 |
| More Details: | This study aimed to analyze the effectiveness of maleimides as inhibitors on the growth of fungal strains isolated from onychomycosis by the solid medium diffusion procedure. The results showed a promising antifungical activity of the assayed maleimides with formation of fungal growth inhibition halos oscillating between diameter 10 and 23mm. MIC was 100µg/mL for 3,4-dichloro-N-phenyl-methyl-maleimide and 3,4-dichloro-N-phenyl-propil-maleimide and 200µg/mL for 3,4-dichloro-N-phenyl-maleimide, 3,4-dichloro-N-phenyl-ethyl-maleimide and 3,4-dichloro-N-phenyl-buthyl-maleimide.Este estudo objetivou analisar a efetividade de maleimidas como inibidores do crescimento de cepas fúngicas isoladas de onicomicoses através da técnica de difusão em meio sólido. Os resultados mostraram destacável atividade antifúngica das maleimidas ensaiadas com a formação de halos de inibição do crescimento fúngico com diâmetros oscilando entre 10 e 23mm. A CIM encontrada foi 100µg/mL para 3,4-dicloro-N-fenil-metil-maleimida e 3,4-dicloro-N-fenil-propil-maleimida e 200µg/mL para 3,4-dicloro-N-fenil-maleimida, 3,4-dicloro-N-fenil-etil-maleimida e 3,4-dicloro-N-fenil-butil-maleimida. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1516-8913 1678-4324 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000500016; https://doaj.org/toc/1516-8913; https://doaj.org/toc/1678-4324 |
| DOI: | 10.1590/S1516-89132006000500016 |
| Access URL: | https://doaj.org/article/e4e689896c1645b889f442938c96d22b |
| Accession Number: | edsdoj.4e689896c1645b889f442938c96d22b |
| Database: | Directory of Open Access Journals |
| ISSN: | 15168913 16784324 |
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| DOI: | 10.1590/S1516-89132006000500016 |
| Published in: | Brazilian Archives of Biology and Technology |
| Language: | English |