Academic Journal
Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model
| Title: | Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model |
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| Authors: | Cécile Hérate, Romain Marlin, Franck Touret, Nathalie Dereuddre-Bosquet, Flora Donati, Francis Relouzat, Laura Junges, Mathilde Galhaut, Océane Dehan, Quentin Sconosciuti, Antoine Nougairède, Xavier de Lamballerie, Sylvie van der Werf, Roger Le Grand |
| Source: | Heliyon, Vol 9, Iss 6, Pp e16664- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | SARS-CoV2, Sotrovimab, Non human primate, BQ.1.1, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19. Recently, both in vitro and in vivo data have suggested that Sotrovimab could retain partial activity against recent omicron sub-lineage such as BA.5 variants, including BQ.1.1. Here we report full efficacy of Sotrovimab against BQ.1.1 viral replication as measure by RT-qPCR in a non-human primate challengemodel. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023038719; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e16664 |
| Access URL: | https://doaj.org/article/4e34389eacbf456083eb7358dd586261 |
| Accession Number: | edsdoj.4e34389eacbf456083eb7358dd586261 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e16664 |
| Published in: | Heliyon |
| Language: | English |