Bibliographic Details
| Title: |
Comparative measurement properties of constant work rate cycling and the endurance shuttle walking test in COPD: the TORRACTO clinical trial |
| Authors: |
François Maltais, Denis E. O’Donnell, Alan Hamilton, Yihua Zhao, Richard Casaburi |
| Source: |
Therapeutic Advances in Respiratory Disease, Vol 14 (2020) |
| Publisher Information: |
SAGE Publishing, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Diseases of the respiratory system, RC705-779 |
| More Details: |
Background: Exercise tolerance is an important endpoint in chronic obstructive pulmonary disease (COPD) clinical trials. Little is known about the comparative measurement properties of constant work rate cycle ergometry (CWRCE) and the endurance shuttle walking test (ESWT). The objective of this sub-analysis of the TORRACTO ® study was to directly compare the endurance measurement properties of CWRCE and ESWT in patients with COPD in a multicentre, multinational setting. We predicted that both tests would be similarly reliable, but that the ESWT would be more responsive to bronchodilation than CWRCE. Methods: This analysis included 151 patients who performed CWRCE and ESWT at baseline and week 6 after receiving once-daily placebo, tiotropium/olodaterol (T/O) 2.5/5 μg or T/O 5/5 μg. Reproducibility was assessed by comparing their respective performance at baseline and week 6 in the placebo group. Responsiveness to bronchodilation was assessed by comparing endurance time at week 6 with T/O with baseline values and placebo. The locus of symptom limitation and end-exercise Borg scales for breathing and leg discomfort for both tests were also analysed. Results: The intraclass correlation coefficients for CWRCE and ESWT were 0.56 [95% confidence interval (CI) 0.37–0.71] and 0.75 (95% CI 0.63–0.84). More patients were limited by breathing discomfort during the ESWT than during CWRCE, whereas more patients were limited by leg discomfort or breathing/leg discomfort during CWRCE than the ESWT ( p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1753-4666
17534666 |
| Relation: |
https://doaj.org/toc/1753-4666 |
| DOI: |
10.1177/1753466620926858 |
| Access URL: |
https://doaj.org/article/4df1f9171d804e3cb85e50d55ae549a9 |
| Accession Number: |
edsdoj.4df1f9171d804e3cb85e50d55ae549a9 |
| Database: |
Directory of Open Access Journals |
