Academic Journal
3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration
| Title: | 3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration |
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| Authors: | Hao Huang, Lei Qiang, Minjie Fan, Yihao Liu, Anchun Yang, Dongbiao Chang, Jinsheng Li, Tong Sun, Yiwei Wang, Ruoyi Guo, Hanjie Zhuang, Xiangyu Li, Tailin Guo, Jinwu Wang, Huan Tan, Pengfei Zheng, Jie Weng |
| Source: | Bioactive Materials, Vol 31, Iss , Pp 18-37 (2024) |
| Publisher Information: | KeAi Communications Co., Ltd., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Element-doped HA-PCL scaffolds, 3D printing, Osteogenic, Osteosarcoma, Antibacterial, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | The resection of malignant osteosarcoma often results in large segmental bone defects, and the residual cells can facilitate recurrence. Consequently, the treatment of osteosarcoma is a major challenge in clinical practice. The ideal goal of treatment for osteosarcoma is to eliminate it thoroughly, and repair the resultant bone defects as well as avoid bacterial infections. Herein, we fabricated a selenium/strontium/zinc-doped hydroxyapatite (Se/Sr/Zn-HA) powder by hydrothermal method, and then employed it with polycaprolactone (PCL) as ink to construct composite scaffolds through 3D printing, and finally introduced them in bone defect repair induced by malignant osteosarcoma. The resultant composite scaffolds integrated multiple functions involving anti-tumor, osteogenic, and antibacterial potentials, mainly attributed to the anti-tumor effects of SeO32−, osteogenic effects of Sr2+ and Zn2+, and antibacterial effects of SeO32− and Zn2+. In vitro studies confirmed that Se/Sr/Zn-HA leaching solution could induce apoptosis of osteosarcoma cells, differentiation of MSCs, and proliferation of MC3T3-E1 while showing excellent antibacterial properties. In vivo tests demonstrated that Se/Sr/Zn-HA could significantly suppress tumors after 8 days of injection, and the Se/Sr/Zn-HA-PCLs scaffold repaired femoral defects effectively after 3 months of implantation. Summarily, the Se/Sr/Zn-HA-PCLs composite scaffolds developed in this study were effective for tumor treatment, bone defect repair, and post-operative anti-infection, which provided a great potential to be a facile therapeutic material for osteosarcoma resection. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X23002098; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2023.07.004 |
| Access URL: | https://doaj.org/article/4de7a5a527764875938db3d43d7a1ef1 |
| Accession Number: | edsdoj.4de7a5a527764875938db3d43d7a1ef1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2023.07.004 |
| Published in: | Bioactive Materials |
| Language: | English |