Bibliographic Details
| Title: |
Association between Dietary Intake, Profibrotic Markers, and Blood Pressure in Patients with Chronic Kidney Disease |
| Authors: |
Abbas Mohtashamian, Alireza Soleimani, Hamid Reza Gilasi, Nejat Kheiripour, Seyed Masoud Moeini Taba, Nasrin Sharifi |
| Source: |
Advanced Biomedical Research, Vol 13, Iss 1, Pp 29-29 (2024) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine
LCC:Biology (General) |
| Subject Terms: |
advanced glycation end products, blood pressure, chronic kidney disease, dietary intake, matrix metalloproteinases, Medicine, Biology (General), QH301-705.5 |
| More Details: |
Background: Among profibrotic and oxidant factors, matrix metalloproteinases (MMPs) and advanced glycation end products (AGEs) have a major impact on the progression of chronic kidney disease (CKD). However, very limited studies evaluated the relationships between nutrient intake and the mentioned factors in patients with CKD. Therefore, the present study aimed to investigate the correlation between dietary intake and the levels of MMPs, AGEs, and blood pressure (BP) in these patients. Materials and Methods: This cross-sectional study was performed on 90 patients with CKD (stages 2–5). To evaluate the dietary intake of patients, three days of 24-hour food recall were completed through face-to-face and telephone interviews. Measurement of MMP-2 and MMP-9 concentration was done by enzyme-linked immunosorbent assay. The fluorimetric technique was used to measure the total serum AGEs. Results: The patients’ average dietary intake of sodium, potassium, phosphorus, energy, and protein was 725 mg/day, 1600 mg/day, 703 mg/day, 1825 kcal/day, and 64.83 g/day, respectively. After adjustment of confounding variables, a significant inverse relationship was observed between dietary intake of insoluble fiber and serum levels of MMP-2 (β = -0.218, P = 0.05). In addition, a significant positive relationship was found between molybdenum (Mo) intake and diastolic BP (β =0.229, P = 0.036). Conclusion: A higher intake of insoluble fiber might be associated with lower serum levels of MMP-2. Also, a higher Mo intake can be correlated to a higher DBP in patients with CKD. It is suggested to conduct future studies with longitudinal designs and among various populations to better elucidate the observed relationships. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2277-9175 |
| Relation: |
https://journals.lww.com/10.4103/abr.abr_204_23; https://doaj.org/toc/2277-9175 |
| DOI: |
10.4103/abr.abr_204_23 |
| Access URL: |
https://doaj.org/article/ea4daf4dba3640acb4e510bb7adbef53 |
| Accession Number: |
edsdoj.4daf4dba3640acb4e510bb7adbef53 |
| Database: |
Directory of Open Access Journals |
