Bibliographic Details
| Title: |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| Authors: |
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell |
| Source: |
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
| Publisher Information: |
Nature Portfolio, 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/ncomms15936 |
| Access URL: |
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f |
| Accession Number: |
edsdoj.4d580842711a47b9a0ba6bb379bd365f |
| Database: |
Directory of Open Access Journals |
