Bibliographic Details
| Title: |
Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease |
| Authors: |
Peijing Yan, Li Zhang, Chao Yang, Wenqiang Zhang, Yutong Wang, Min Zhang, Huijie Cui, Mingshuang Tang, Lin Chen, Xueyao Wu, Xunying Zhao, Yanqiu Zou, Jinyu Xiao, Yunjie Liu, Chenghan Xiao, Yanfang Yang, Ling Zhang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Chunxia Yang, Xia Jiang, Ben Zhang |
| Source: |
Frontiers in Endocrinology, Vol 14 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
type 2 diabetes mellitus, gallstone disease, Mendelian randomization, bidirectional, causal relationship, genetic association, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
BackgroundThe relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms underlying these associations.MethodsWe first evaluated the phenotypic association between T2DM and GSD using data from the UK Biobank (n>450,000) using a prospective observational design. We then conducted genetic analyses using summary statistics from a meta-analysis of genome-wide association studies of T2DM, with and without adjusting for body mass index (BMI) (Ncase=74,124, Ncontrol=824,006; T2DMadjBMI: Ncase=50,409, Ncontrol=523,897) and GSD (Ncase=43,639, Ncontrol=506,798).ResultsA unidirectional phenotypic association was observed, where individuals with T2DM exhibited a higher GSD risk (hazard ratio (HR)=1.39, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1337071/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1337071 |
| Access URL: |
https://doaj.org/article/4d4e8d144a4d4c33bbca0b97020d7f9c |
| Accession Number: |
edsdoj.4d4e8d144a4d4c33bbca0b97020d7f9c |
| Database: |
Directory of Open Access Journals |
